2 Million Dogs – The Blog

Cancer. Touches. Everyone.

Auburn University in Alabama Testing Bone Cancer Treatment for Dogs

Posted by Erich Trapp on May 13, 2013

Many of the dogs we have met through the 2 Million Dogs Foundation, and earlier with 2 Dog 2000 Miles, have suffered from bone cancer (osteosarcoma). This article, by Evan Belanger, details how Auburn University is testing a new treatment for osteosarcoma. You can find the complete article here as well.

Auburn testing bone-cancer treatment for dogs that could increase survivability and translate to human treatments

 

Pictured is Lily Johnson. “Most dogs suffering from bone cancer must have the impacted leg amputated. In more than 90 percent of cases, the cancer cells migrate to the lungs, creating demand for new treatments.”

Pictured is Lily Johnson.
“Most dogs suffering from bone cancer must have the impacted leg amputated. In more than 90 percent of cases, the cancer cells migrate to the lungs, creating demand for new treatments.”

By Evan Belanger

AUBURN, Alabama — Auburn University is testing a new treatment for bone cancer in dogs that a university veterinarian says could one day be broadened to treat human cancers.

The American Kennel Club Canine Health Foundation has awarded Bruce Smith, director of the Auburn University Research Initiative in Cancer, a two-year grant totaling $118,848 to test the new therapy.

The treatment consists of a virus normally used as a hepatitis vaccine in dogs that has been modified to only make copies of itself when inside cancer cells.

It ruptures the cancer cells, killing them and releasing thousands of copies to attack other cancer cells.

“By using this approach, we turn the cancer cell into a factory that produces more virus,” Smith said. “You could say that we help the cancer cell become an agent of its own death.”

The immediate goal of the study is to prove the efficacy of the new treatment for bone cancer, but Smith said the long-term goal is to create a single treatment that can treat multiple types of cancer in dogs.

The lessons learned could also be used to create new treatments for human cancer and could lead to human trials in partnership with a medical college, he said.

“Ultimately, we want that to be a clinical treatment in dogs,” Smith said. “But it’s also something that’s going to tell us something about how to use this approach in people, so we’re very big on this idea of one medicine.”

Bone cancer in dogs, which accounts for about 5 percent of tumors in dogs, has a very poor survival rate.

In most cases, the dog’s leg is amputated to make the dog more comfortable and remove the tumor, but the cancer cells migrate to the lungs more than 90 percent of the time.

In those cases, dogs that receive chemotherapy typically only live nine to 12 months post diagnosis, creating demand for more effective treatments.

“This therapy attacks those metastases and will hopefully eliminate them or make them more sensitive to chemotherapy,” Smith said.

The study will involve 20 dogs over two years. All dogs must be referred by a veterinarian and must have all four legs intact so researchers can collect live cancer cells from the tumor.

The grant will cover the cost of the viral treatment, but owners must pay for the cost of amputation and chemotherapy, treatments with which the viral injection is intended to work in conjunction.

The Auburn University Research Initiative in Cancer was founded in 2012 to accelerate the translation of cancer innovation from the laboratory to the clinic.

AURIC follows a “one-medicine” concept that views human and animal health as a single field where discoveries in one species advances health in both species.

“Dogs are actually very similar physiologically to people, and a lot of the cancers they get have the same gene mutations,” Smith said.

“Tumors like breast cancer is very, very similar between dogs and humans. Dogs get skin cancer, dogs get blood cancers that are similar to human cancers, dogs get brain cancers that similar to human cancers … so what we learn in dogs is very applicable to humans.”

 

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2 Million Dogs — Our Mission

Posted by Erich Trapp on March 13, 2013

2MillionDogs.org

Our Mission

2 Million Dogs Foundation is a 501c3 non-profit organization, and our ongoing commitment is discovering the common links between canine and human cancers and the causes of these cancers through comparative oncology research. Our organization is accomplishing that mission in the following ways:

Education and Awareness
The field of comparative oncology is relatively new and 2 Million Dogs continues to educate people about its tremendous potential through a global campaign of strategic partnerships, seminars, speaking engagements, social media, events, broadcasts, and other forms of media.

Empowerment and Mobilization
Through our The Puppy Up! Walks, we are building the largest pet and people cancer community in the world; from business people to artists to scientists and humanitarians, we are forging partnerships with individuals and institutions with the singular purpose of ridding the world of one of its deadliest diseases.

Investment in Research
2 Million Dogs scientific objectives are: Broadening our understanding of the links between human and companion animal cancer, creating a cross institutional collaborative platform, developing new approaches to research, and funding translational cancer studies that benefit both pets and people.

About Cancer

Like people, companion animals develop cancer – they get brain, breast, bone and lung cancer; lymphoma, and melanoma just to name a few, and scientists have discovered that the malignant cells are biologically comparable between humans and our companion animals.

Furthermore, cats and dogs are exposed to the same environmental risks, so if we hope to eradicate cancer there is tremendous potential in forming a partnership between pets and people.

Benefits of Comparative Oncology

There is a large population of cats and dogs with pre-existing cases of cancer

Cancer occurs in pets within years compared to decades in humans

Veterinarian Oncologists believe there are between 4 and 8 million new cases of cancer in companion animals every year. Most of those never receive adequate care or treatment.

Increasing the number of comparative oncology studies means more and more dogs and cats will have access to the latest treatments.

It’s important to note – comparative oncology studies do NOT involve animal testing. The companion pets that participate have naturally occurring cancer  ̶  the cancer has already developed in the animal; it was not induced. This means that one of the potential long-term benefits of these studies could be reducing our reliance on animal testing.

pupperDo You Know The 10 Early Warning Signs?

Love your dog? Learn the 10 L’s

Lumps

Not all lumps and bumps are cancerous in dogs. There are sebaceous cysts, lipomas, and warts, all of which are benign. But if you detect a growth on your dog it’s important to have it checked out by a veterinarian and, if warranted, aspirated and biopsied.

Lesions

Scratches and abscesses are not uncommon for the normal, active dog but the sores that don’t heal can be of concern.

Lameness

Bone cancer is typically found in larger breed dogs like Great Danes, Bernese Mountain dogs, Rottweilers, Boxers, Newfoundlands, Saint Bernards, and Great Pyrenees, and the primary early indication is prolonged limping or favoring a limb or side. Other types of cancers can also cause persistent lameness.

Loss of Appetite

If your dog shows no interest in eating or their daily consumption has declined for several days, take them to a vet.

Lethargy

Tiring out easily, unwillingness to exercise and loss of interest in normal daily activities can be an early sign of cancer.

Loss of Weight

Not to be confused with loss of appetite. Cachexia, or emaciation, is often associated with cancer and can occur even if your dog is still eating normally. So if your dog is inexplicably losing weight, consult a veterinarian.

Loud Odor

A very strong and offensive smell can sometimes be a byproduct of tumors in the mouth and nasal cavity.

Loss of Normal Body Functions

Dogs having difficulty voiding or defecation or unusual urine or feces should be looked at.

Loss of Blood, Bleeding or Bloody Discharge

Blood present in vomit, stool, and nasal discharge are cause for serious concern and although not always telltale signs of cancer, your dog should be examined as soon as possible.

Labored Breathing

Abnormal respiration or respiratory distress can be a symptom of cancers in dogs.

 

Come and get involved!   To find out more about the 2 Million Dogs Foundation, our nationwide Walks, our yearly calendar, our other fund-raising events, and the research our efforts support, please visit our web page

And please come join us on Facebook, follow the adventures of Hudson and Indy, and follow us on Twitter

For more information, please contact us by writing to our Executive Director, Ginger Morgan, at ginger@2milliondogs.org.

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Orchard School 4th Grade Business Project Donates Generously to 2 Million Dogs

Posted by Erich Trapp on March 5, 2013

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Luke, Indy, Carly, and Hudson.

Recently, 2 Million Dogs received word that a generous donation was made to our Foundation, thanks to the efforts of Carly Levinsohn and the heartfelt appeal she made to her fellow classmates in a 4th grade business project at Orchard School in Indianapolis, Indiana. Below is her letter to her classmates, and a letter to us. Thank you Carly and everyone who contributed so thoughtfully to our organization on behalf of dogs with cancer.

We applaud the efforts of this young generation, and the hard work that went in to supporting a cause they believe in. Thank you.

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Carly presenting a check to Luke Robinson, founder of 2 Million Dogs.

Posted in Fundraiser, Research, Stories | Tagged: , , , , , , , , | 2 Comments »

Pre-Order Your 2013 Calendars for the Holidays

Posted by Erich Trapp on November 2, 2012

Lily Lisle, this year’s Cover Girl. Lily was touched by cancer three different times.

Time to Pre-Order Your 2013 Calendars for the Holidays

Our “Cancer Can’t Keep a Good Dog Down” calendars get better every year, and this year is no exception. Check out the 2013 cover. (Pictured is Lily Lisle, who fought 3 different cancers.) Please pre-order your calendars now. They make great gifts, are wonderful keepsakes, and every one of your friends and relatives should have at least one (if not more). And don’t forget your vet, your groomer, and your pet-sitter. Please follow this link and order now. Calendars are only $15.00 plus S&H.

We’d like you to know that your continued financial support of this year’s 2 Million Dogs’ calendar has enabled us to contribute $20,000.00 to our first canine cancer study with The Broad Institute of Harvard and MIT. This year, the 13 winners of the calendar contest were given the opportunity to choose from three of Broad’s canine cancer research projects, and they chose the osteosarcoma study. Osteosarcoma is the most common bone tumor of the dog. This cancer develops in the bone, usually the limbs, and as the tumor grows it becomes progressively more painful for the dog and can result in lameness. Often these tumors metastasize to the lungs.

Why does 2 Million Dogs choose to support Broad? Dogs and humans get many of the same diseases, including cancer. Studying DNA from both healthy and sick dogs can help researchers gain insights into diseases that affect both species. That work helped lay the foundation for a variety of studies into the genetic basis of disease — research that depends on help from dogs as well their human companions.

We commend Broad’s philosophy of sharing disease exploration across the research spectrum. Additionally, their work is international, which widely broadens their field of inquiry and the potential for groundbreaking discoveries because Broad Institute brings together a diverse group of individuals from across its partner institutions — undergraduate and graduate students, postdoctoral fellows, professional scientists, administrative professionals, and academic faculty. The culture and environment at the Broad is designed to encourage creativity and to engage all participants, regardless of role or seniority, in the mission of the Institute. Within this setting, researchers are empowered — both intellectually and technically — to confront even the most difficult biomedical challenges.

Thanks to you and everyone who participated in the contest, and purchases the calendar, we are able to contribute to Broad’s continuing pioneering research.

(Our terrific calendar is designed again this year by Brian Kristensen of Colorcodemedia.com.)

Posted in 2013 Calendar Contest, Fundraiser, Research | Tagged: , , , , , , , , , , | 2 Comments »

From Puppy Up! Denver

Posted by Erich Trapp on November 1, 2012

“The Dog” by Francisco Goya.

I found the artwork posted by Puppy Up! Denver on Facebook so compelling I wanted to share it with all our blog readers.

Puppy Up! Denver writes:

One in three. One in three. ONE IN THREE. That is how many dogs get cancer, and they get the same cancers people do. Cancer doesn’t care that it already kills 7 million people a year. It will kill half of those one in three dogs each year too. But it doesn’t have to — and that’s why we walk this weekend, the first [weekend] in November, which is National Canine Cancer Month. STOP CANCER IN ITS TRACKS. Because Cancer. Touches. Everyone.

[PAINTING: *The Dog* by Spanish artist Francisco Goya. Oil mural on plaster transferred to canvas, 51¾ × 31¼ inches. Painted on the walls of Goya's small house on the bank of the Manzanares River between 1819 and 1823, when he was at work on his series *The Disasters of War* and wanted to surround himself at home with something more inspiring, for his own pleasure (though his mood darkened the longer he worked on the war series). Never intended for public viewing, the fourteen works featuring dogs were removed fifty years after his death, now on display in the Museo del Prado, Madrid. Antonio Saura, one of Spain's most influential modern painters and writers, called *The Dog* "the most beautiful painting in the world."]

There’s still time to participate in this year’s Puppy Up! Walks around the country. Please follow this link and join us.

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We’re Mobile!

Posted by Erich Trapp on November 1, 2012

Yes, we are. You can now go mobile with 2 Million Dogs (2MD). Start receiving text alerts now. Text 2MD 55678.

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Notice to Puppy Up! Jersey City Supporters

Posted by Erich Trapp on October 31, 2012

From the organizers of Puppy Up! Jersey City, we just received this:

Dear Puppy Up! Jersey City supporters,

Due to the devastation of Hurricane Sandy, City of Jersey City has understandably canceled all events for the upcoming weekend including Puppy Up!

We wish everyone in the area well as we recover and restore.

In response to your questions – Although we will not physically Walk the Walk, we continue to strive to reach our goal of $10,000. So, we encourage all supporters to visit us online and:

1. “register” to walk by Nov 1st;
2. Fundraise through Nov 4th;
3. Sponsor a team, walker or fundraiser by donating to them by Nov 4th;
4. Donate to Puppy Up! Jersey City by Nov 4th.

http://PuppyUpJC.kintera.org/faf/home/default.asp?ievent=1034488

Because our availability is limited as we recuperate in Jersey City, please follow our Facebook and Kintera walk pages for updates. Thank you for your help and support… Puppy Up!

All the best to everyone who has met Sandy.

2 Million Dogs extends its heartfelt good wishes to ALL our friends, supporters, sponsors, and walkers throughout all the areas affected by Hurricane/Superstorm Sandy.

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Us In A Nutshell — Thanks, Chicago Tribune

Posted by Erich Trapp on October 11, 2012

Up Close and Personal — Melisa Kottmeier makes friends with Indy, one of two Great Pyrenees dogs owned by Luke Robinson, founder of the 2 Million Dogs organization, who spoke to dog owners at FYDO Land in Elgin about links between human and pet cancer. (photo by Darrell Goemaat)

The Chicago Tribune recently covered the story of 2 Million Dogs and did such a great job, we’d like to share it here in case you missed it.

“It’s [the article] not just about 2 Million Dogs.” says Executive Director Ginger Morgan, “It’s about how people live with cancer every day. By sharing this article you could be helping someone realize that they are not alone in their fight.”

The article was written by Amanda Marrazzo, Special to the Tribune. Photo credit is Darrell Goemaat, with the Chicago Tribune.

If you’d like to keep up with the work of 2 Million Dogs, you can set Google to do a Google Alert. How? Follow this link for simple directions.

Now, here’s the Chicago Tribune article …
October 10, 2012

When his beloved Great Pyrenees dog Malcolm died from bone cancer in 2004, Luke Robinson was sad and angry.

Adding to his loss: Nobody could tell him why.

“I didn’t even know dogs could get cancer,” Robinson said.

Beginning in 2008, Robinson and two of his other dogs, Murphy and Hudson, walked from his home in Texas to Boston to raise awareness about cancer in pets and links to human cancers as well. With stops and starts along the way, and Robinson and the dogs camping or staying with host families, the journey lasted more than two years.

“Somewhere on the cross-country walk I had this dream, this vision of taking the two dogs, walking 2,000 miles and making that into 2 million dogs,” he said.

And so his life’s mission was conceived. After the walk ended, the not-for-profit 2 Million Dogs was founded with the hope that eventually that number of canines and their owners will participate in walks to raise awareness and money to fund research to eradicate cancer from pets and people.

Humans share no direct genetic link with dogs, yet each dies from the same types of cancers in astronomical numbers, he said.

Sadly, Murphy was diagnosed with nasal cancer less than a month after arriving in Boston. He died a year and three days later.

Losing Murphy further strengthened his resolve.

“I think dogs are the canary in the coal mine,” he said. “I think that they hold the answer. They drink the same water we do, are exposed to the same air, environmental toxins. I can’t help to think since we don’t share a genetic link, there must be something in the environment.

“All the cancers we get, they are getting too,” he said. “And that is strange. … We share no evolutionary line with dogs. We don’t come from dogs and dogs don’t come from us.”

Robinson recently visited the Chicago area with Hudson and Indy, his newest “fuzzybutt,” on what he named the “Summer of Murphy Tour,” a cross-country journey in his van that he began in September.

He visited with local veterinary oncologists and met with dog lovers in Elgin and Schaumburg.

Robin Massey, owner of FYDO Land, dog day cares in Elgin and Huntley, said she was so moved by the mission at an event she attended last summer she became a co-chair of the local group.

“Unfortunately, being in the business I’m in, I have lost a lot of four-legged friends to cancer,” she said. “It’s not only about fighting cancer in canines, but about fighting cancer in everybody. It’s an all inclusive group.”

Since 2010, through events called Puppy-Up walks, 2 Million Dogs has raised $270,000, said Karyn Vasquez, a dog lover and member of the board of directors of the organization. About a third of the money goes to research, with the rest going toward education and awareness.

“For me, just letting people know that our companion animals really do get cancer is a huge step in the right direction,” said Vasquez, who lost her own dog, Chelios, to lymphoma on New Year’s Day 2010.

Last year the organization presented a $50,000 grant to Princeton University to fund the school’s study of canine mammary tumor development and progression.

“Mammary tumors are the most common tumors in intact female dogs,” she said. “In humans, breast cancer is the most commonly diagnosed cancer in women. Mammary tumors in dogs and breast cancer in women have many similarities, both in terms of risk factors and biology.”

Interest in the mission has grown.

In 2010 there were Puppy-Up walks in 12 cities across the United States. In 2011, there were walks in 27 cities, and this year there are about 32. So far, about 3,000 dogs and their owners have participated, said Ginger Morgan, executive director of 2 Million Dogs.

“We are still looking for many dogs and their owners to help us in our fight against cancer,” Morgan said, encouraging owners to bring their dogs to a Nov. 3 walk in West Dundee.

“When we hit 2 million dogs, we will still continue walking. We’ll walk until we find a cure, until we can find out what is causing cancer and how we can prevent it.”

Heather Neal, of Aurora, like Robinson, also believes that cancers, as well as other ailments, in both humans and canines are caused by the environment we live in, the food we eat, the water we drink and the air we breathe.

She owns Cadence, an 8-year-old standard poodle, who last year received treatment for osteosarcoma, a malignant bone cancer. After undergoing chemotherapy, the amputation of her right back leg, a switch to a raw food diet and a daily cocktail of herbal supplements, Cadence is doing much better and today is cancer-free.

“She is vibrant, full of life, energetic,” Neal said. “Being on three legs has not stopped her at all. She is like a tornado.”

Neal believes humans have a spiritual connection with their dogs, and that dogs are the key to unlocking the mysteries of cancer.

“They are more than just pets to us; they are a family member,” she said. “Let’s do what we can to cure (cancer). It will be good for dogs and human beings.”

Dr. Tiffany Leach, a veterinary oncologist who works at Specialty Vets in Buffalo Grove, said there are cancers that behave the same in humans and dogs, and there are also treatments that work on both human and dog cancers.

For example, sarcomas behave the same in children as they do in dogs, and there are medicines that can be used to treat both, Leach said.

“Vet oncology is so important to us because we can take a lot of the human cancers and get information to use for dog cancers,” she said.

As a resident at Purdue University she worked on a study of bladder cancer. It was found that the same treatments used for human bladder cancer were effective when used to treat bladder cancer in dogs.

It’s also been proved that pediatric osteosarcoma, or bone cancer, displays the same behaviors in children and dogs. And doctors are able to use the same treatments as veterinarians in treating it.

Leach also believes environmental factors play a role in canine and human cancers. But she also believes certain breeds tend to be prone to specific cancers. For example, she said, a Bernese mountain dog is prone to histiocytic sarcoma, an aggressive cancer that begins in the muscle tissue.

Leach herself knows firsthand the pain of dealing with cancer on more than one level. Her grandfather suffered with prostate cancer, which first led her to studying oncology along with veterinary medicine.

In 2005, she was diagnosed with renal cell carcinoma, or kidney cancer. Though she declined to go into detail about her health, she has gone through treatments and at least two surgeries, and simply said, “I’m handling it. I’m still able to go to work and lead a pretty normal life.”

Then there are her two beloved Irish wolfhounds, which each have dealt with their own cancers. Gideon, 6, had a soft-tissue sarcoma. The dog has had surgeries and radiation and is in remission. Jiggs, 9, was diagnosed with chondrosarcoma, a type of a bone cartilage tumor. Jiggs underwent surgery two months ago and seems to be in remission, she said.

All of these situations have confirmed that the profession she has chosen as her life’s work is exactly where she should be. She knows the struggles of cancer. She knows the heartache of a pet having a life-threatening disease. So when sitting with a pet owner and telling them their pet has cancer, she can honestly say she knows how they feel.

“You can at least genuinely say, ‘I’ve been through this and I understand,’ and you can really mean it on a level I couldn’t have had,” she said. “I’ve been lucky in that respect. I’m an undying optimist. I like to take the positive out of all of this.”

Robinson, meanwhile, is off to another city. His message is for all people, those with and without pets, and those who have or have not been affected by cancer.

“We are facing nature’s perfect enemy,” Robinson said. “No man, woman, child or companion animal is spared its killing field.”

A 2 Million Dog Puppy-Up will be held Nov. 3, at Randall Oaks Park, 1180 N. Randall Road, West Dundee. Registration is 10 a.m., opening ceremonies at 11:15 a.m., and a two-mile walk steps off at 11:30 a.m. Closing ceremonies will be at 12:30 p.m.

Preregistration by Nov. 1 is $20 per person (under the age of 14 is free). Day of walk registration is $25 per person. No limit on the number of dogs.

Dogs must be up to date on vaccinations and must not be on a retractable leash.

Posted in Events, Fundraiser, Puppy Up! Walks, Stories, Summer of Murphy Tour | Tagged: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | 2 Comments »

Thank You, Orchard Park School Students!

Posted by Erich Trapp on October 5, 2012

Luke with student Carley Levinsohn presenting a check for over $400.00 to 2 Million Dogs. (Photo by Make Corbin of WIBC)

As reported by Mike Corbin with WIBC, 93.1FM,  some enterprising Indiana grade schoolers led by one young lady are doing their bit for cancer research.

Students at Orchard Park School in Indianapolis, Indiana donated the $400 they raised to 2 Million Dogs Thursday.

Fifth-grader Carly Levinsohn heard about the group. She was on hand to present the check to Robinson and his dogs Indiana and Hudson outside the school (pictured).

As part of a class assignment to build a business, Carly and other students in her class chose to donate their profits to the group. Carly says she hopes the money helps researchers cure cancer in dogs and people. Robinson says the donation is important because it will help toward that end. He adds that raising awareness is also crucial. Robinson says many people don’t know that pets can also get brain, breast and other types of cancers and that the disease has a similar physiological makeup in dogs as in humans.

 

Thank you Carly and all the kids who Puppied Up! and made the donation happen.

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The 14th Of …

Posted by Erich Trapp on October 3, 2012

Ginger Morgan with Murphy, Luke Robinson with Hudson, and a multitude of friends and supporters walking the final mile together in Boston.

So Luke had this idea a while back.

If 2 dogs could walk 2,000 miles for cancer we could get 2 million dogs all over the country to walk.  On the same day and at the same time. I’m a very visual person and the impact of that would send shockwaves across the nation.  Literally – if we had a bunch of big dogs pounding the pavement in synchronicity.  

We chose the first Sunday in November for no reason other than auspicious weather in most parts of the country and out of respect for other walks.

This year, we have 25 cities walking on the exact same day (the others are rebels) but the Fuzzybutts can only be at one of them.  And this year, it’s the final stop on the first Summer of Murphy tour and I have something special in store and you don’t want to miss it. 

But it’s not up to me.  It’s up to you.  The city that raises the most money by October 14th is where we’ll be and you can click here to sign up for your local walk, start a team, and start fundraising. 

Posted in 2012 Puppy Up! Walks, Events, Fundraiser, Puppy Up! Walks, Summer of Murphy Tour | Tagged: , , , , , , , , , , , , | Leave a Comment »

 
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