2 Million Dogs – The Blog

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Posts Tagged ‘canine cancer clinical trials’

New Procedure at Texas A&M May Aid in Treatment of Osteosarcoma

Posted by Erich Trapp on November 28, 2011

Kate Cordts with her dog Rowdy pose for a photo on November 17, 2011. Photo: SAN ANTONIO EXPRESS-NEWS, JUANITO GARZA / By Melissa Ludwig, mludwig@express-news.net

Portions of this article are reprinted under the Fair Use Doctrine covering  news reporting and research. You may find the full article here. (From San Antonio Express News)

When Kate Cordts  noticed swelling on the foreleg of her Great Pyrenees, Rowdy, she knew exactly what it was. Bone cancer.

“One of my previous dogs had the same disease. We had to put him down because it was too far along,” said Cordts, a librarian at the San Antonio Public Library.

A trip to the vet confirmed her suspicion, but this time she wasn’t ready to give up without a fight.

Putting her research skills to work, she found an experimental treatment at Texas A&M University’s veterinary school that could save her dog’s leg — and one day maybe the lives of children suffering from osteosarcoma, or bone cancer.

On Friday, Theresa Fossum, a veterinary surgeon at the Texas A&M Institute for Preclinical Studies in College Station, injected radioactive isotopes into Rowdy’s bone using tiny drills about the size of two human hairs. Researchers will watch the results carefully to see if the cancer shrinks and if the treatment could hold promise for humans.

“One of the reasons it costs $1.2 billion to get a new drug on the market is that most fail in clinical trials,” Fossum said. “Many get tested in mice with no immune system so they can grow a human tumor. Dogs are good models; they probably get cancer for the same reasons as humans and have an intact immune system.”

… Around 10,000 dogs a year develop osteosarcoma, which seems to favor large dogs like St. Bernards. The disease strikes about 900 humans each year in the U.S., many of them children under 15.

… “Many people say it is ridiculous to spend money on a pet. But in fact, we learn so much in treating these dogs and having them observed, it becomes an invaluable part of the overall research program,” Stan Stearns, the  Houston entrepreneur said.

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What is Comparative Oncology?

Posted by Erich Trapp on February 4, 2011

Today is World Cancer Day. Much of the focus is on human cancers and what can be done to prevent and cure them. But comparative oncology goes beyond human cancer studies to incorporate canine patients as well.

Humans and dogs have been partners over the centuries, and now we’re again helping one-another, through the field of comparative oncology, to understand cancer, teaming up with our best friends to develop studies and treatments that “span the species.” There is an excellent overview of comparative oncology and how doctors and veterinarians are collaborating in understanding the parallels, as well as the differences, in canine and human cancers, presented by The Land of Pure Gold. Click here to visit their page and learn about:

• environmental risks of cancer
• the predisposition of some breeds for certain types of cancers
• therapeutic strategies for a variety of cancers
• cancer and gene imaging systems
• clinical trials
• cancer clues in dogs
• cancer resistance

as well as a host of other invaluable resources.

And please visit our web page for a list of the early warning signs of canine cancer.

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22 Stones

Posted by Erich Trapp on January 7, 2011

This blog is re-posted from Luke’s original post of January 4th, 2011.


Don’t know where I left off last with Murphy’s condition but Christmas week we reached critical mass. He was struggling and I wasn’t sure if he’d make it.

I didn’t think the massive radiation doses administered over three days would alleviate his airways quickly enough for him to breath sufficiently which is why I explored radical ideas like inserting a shunt or stent.

But the radiation did work and it didn’t take the two weeks that was speculated. By Christmas day Murphy was playing with Hudson for the first time in weeks and it was a very special day. That’s a photo of Murphy taking off with his X-Mas booty that I entitled, “Kthnxbye”.

We were blessed with a mostly uneventful week following Christmas during which I turned 40 and then the Earth added another year to the 4.54 billion and change it has under its belt.

I say mostly because Murphy has had nosebleeds and down days but he’s still markedly better than two weeks ago. However, that radiation was so effective so quickly suggests serious side effects are in store. Already Murphy’s losing fur on his head and around his eyes that never fully re-grew from the first round but we knew that hitting the tumor hard would be risky.

We are due to return to CSU this morning for a clinical evaluation to assess whether he’s a candidate for adjunct chemotherapy though my mind’s pretty much already made up since the ‘wait and see’ approach after radiation last August was a complete failure. Had I run parallel courses then we may have been in a different place now.

Which is perhaps the lesson for the week. When it involves cancer always assume the worst and choose the most aggressive form of therapy. I’m listening to The Emperor of All Maladies on CD now (which I highly recommend) and while it’s chocked full of interesting metaphors I’m a movie kinda guy.

While writing this blog The Terminator came to mind when Reese is trying to convey the seriousness of the situation to Sarah Connor. “It can’t be bargained with. It can’t be reasoned with. It doesn’t feel pity or remorse. And it absolutely will not stop. Ever. Until you are dead.”

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Current Clinical Trials at the The University of Missouri

Posted by Erich Trapp on December 21, 2010

Cancer Patients Sought for Funded Clinical Trials

The University of Missouri is currently seeking patients for enrollment in funded oncology clinical trials. Study goals and suitability for each patient are discussed in detail with the clients prior to enrollment. Although clinical trial enrollment may not be the best option for all patients, in many cases, clinical trial participation provides the opportunity to receive novel, cutting-edge therapies free of charge or at a reduced cost and may facilitate treatment of pets where it would not otherwise be possible due to financial constraints or lack of other therapy options. Criteria for enrollment are outlined for each tumor type. Please direct referrals or questions to Debbie Tate, RVT (clinical trials coordinator) or the Oncology Clinical Trials Service at 573-882-7821.

For the full article, please follow this link.

There is quite an extensive list of studies on their website. Scroll down their page for more information on:

• Palladia™ for Canine Splenic Hemangiosarcoma
• Inhalant chemotherapy for canine lung cancer (NOT OPEN YET)
• Radioactive Gold Nanoparticles or Palladium Brachytherapy for imaging and treatment of canine prostate cancer
• Tavocept use to mitigate nephrotoxicity associated with cisplatin and piroxicam treatment of canine bladder cancer
• Bcl-2 Canine Lymphoma Study
• AD-198 Canine Refractory Lymphoma Study
• CycloSam™ (Sm-153-DOTMP) OSA Study
• Echocardiographic and Total Body Water Evaluation of Canine Lymphoma

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